The occurrence and development of early invasive breast cancer were often accompanied by axillary lymph node metastasis and accurate axillary lymph node staging plays an important guiding role in the selection of local treatment plan, systemic comprehensive treatment decision, and prognosis judgment. Introductionīreast cancer is one of the common female malignant tumors with high morbidity and mortality. The formation of vascular tumor thrombi in breast cancer tissue and left breast cancer are risk factors for axillary lymph node metastasis in invasive breast cancer and might be helpful for preoperative detailed assessment of the patient’s condition. Binary logistics regression analysis showed that LVI (OR =12.258, 95% CI =3.681-40.812, ) and left breast cancer (OR =3.598, 95% CI =1.404-9.219, ) were risk factors for axillary lymph node metastasis in patients with invasive breast cancer. There were no significant differences in the imaging parameters obtained by DCE-MRI between the two groups. The proportion of breast cancer on the left side in the ALNM group was higher than that in the NALNM group, and the difference was statistically significant (70.00% vs. The proportion of LVI in ALNM group was significantly higher than that in NALNM group (37.50% vs. ![]() ![]() No significant differences were found in the positive rates of HER-2, ER, PR, Ki-67, pathological types, and clavicular lymph node metastasis and skin chest wall invasion between the two groups ( ). There was no significant difference in general demographic information between the two groups. The variables with differences between the two groups were compared by univariate analysis, and the related factors of axillary lymph node metastasis were analyzed by logistic regression model. Imaging parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) including apparent diffusion coefficient (ADC), early enhanced rate, and time-intensity curve (TIC) were also included into univariate analysis. Collected pathological results included lymphovascular invasion (LVI) and the expression of estrogen receptor (ER), progestogen receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 detected by immunohistochemistry. General demographic information was collected and compared between the two groups. According to postoperative pathological results, axillary lymph node metastasis was divided into axillary lymph node metastasis (ALNM) group ( =40) and non-axillary lymph node metastasis (NALNM) group ( =82). This study retrospectively included 122 cases of invasive breast cancer patients admitted to the First Medical Center of PLA General Hospital from January 2019 to September 2020. To investigate the risk factors of axillary lymph node metastasis in patients with invasive breast cancer.
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